ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
TNFAIP3, NKIRAS2
ncRNA Pathway:
NF-kappaB pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The role of miR-125b in glioblastomas cells was detected using lentiviral and retroviral, transduction, luciferase activity assays, cell cycle analysis, apoptosis assay, cell viability assay,Real-time PCR, western blot, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line ( U87 MG, LN-18, U251, HS683, T98G)
Other information
Title:
miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas.
Journal:
Cell Death Dis
Published:
2014
PubMed ID:
24901050