ncRNA basic information
ncRNA ID: ENSG00000251562
ncRNA Database: Ensembl
ncRNA Name: MALAT1
ncRNA Type: lncRNA
ncRNA Expression: down-regulated
ncRNA Method: RT-qPCR
ncRNA Target Gene: NA
ncRNA Pathway: miR-203-TS pathway
Evidence (ncRNA-drug): validated
drug basic information
Drug ID: DB00853 (APRD00557)
Drug Name: Temozolomide
Drug Method: The expression levels of lncRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells .
Drug Response: sensitive
Cancer basic information
Cancer: glioblastoma
Tissue/Cell: cell line ( U87 and U251)
Other information
Title: MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression.
Journal: Oncotarget
Published: 2017
PubMed ID: 28187000