ncRNA basic information
ncRNA ID:
MI0000802
ncRNA Database:
miRBase
ncRNA Name:
miR-340
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Nrf2
ncRNA Pathway:
Nrf2-dependent Antioxidant Pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time quantitative PCR (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells,
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line (HepG2,HepG2/CDDP)
Other information
Title:
miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway.
Journal:
Asian Pac J Cancer Prev
Published:
2014
PubMed ID:
25556489